The leading ketamine infusion clinic in Winston-Salem, NC

Provider Referral

Help Us Improve Patient Outcomes Through Our Provider Referral Program

We are excited to let fellow providers know about a new service at Restoring Wellness Solutions. We are offering patients with an existing diagnosis of certain mood disorders intravenous ketamine infusions in the comfort of our office in Winston-Salem.

Ketamine has been shown to treat mental health disorders by acting on the glutamate receptor. Ketamine is an N-methyl-D-aspartate receptor antagonist that increases glutamatergic activity in the brain’s prefrontal cortex. Increases in glutamate lead to activation of signaling pathways and an increase in brain-derived neurotrophic factor (BDNF). Increased levels of BDNF lead to neuroplastic changes, including synaptogenesis and reversal of neuronal atrophy.

As the lead provider at Restoring Wellness Solutions, Anna Plummer-Roberts, MSN, CRNA, has provided anesthesia services to patients in the operating room in the Triad region since 2015. Ketamine is primarily an anesthetic agent that received FDA approval in 1970 and is frequently used in the operating room today. Anna brings her expertise in administering anesthesia, patient safety, and comfort to Restoring Wellness Solutions. We thoroughly monitor our patients throughout their infusion and recovery period with the ability to respond quickly to any side effects or crises that arise.

How the Referral Process Works

We welcome referrals from other primary care and psychiatric care providers for patients that may benefit from ketamine infusions. We will share the patient’s responses to treatment with this provider to incorporate into the patient’s overall treatment plan. The referring provider will also guide adjustments to any psychiatric medications based on their response to ketamine therapy.

Patients are also welcome to send their referral form(s) or a written prescription for ketamine therapy. Any of these forms of documentation are acceptable.

Healthcare providers may fax the referral form(s) to us at 336-502-1064.

We are happy to discuss ketamine infusions as an option for patients or share resources for your review. Feel free to reach out to Anna Plummer-Roberts, MSN, CRNA, by email or phone.

  1. Ketamine infusions for Treatment Resistant Depression

Sakurai, H., Jain, F., Foster, S., Pedrelli, P., Mischoulon, D., Fava, M., & Cusin, C. (2020). Long-term outcome in outpatients with depression treated with acute and maintenance intravenous ketamine: a retrospective chart review. Journal of Affective Disorders, 276, 660-666.

https://www.sciencedirect.com/science/article/pii/S0165032720325349

 

McIntyre, R. S., Rodrigues, N. B., Lee, Y., Lipsitz, O., Subramaniapillai, M., Gill, H., … & Rosenblat, J. D. (2020). The effectiveness of repeated intravenous ketamine on depressive symptoms, suicidal ideation, and functional disability in adults with major depressive disorder and bipolar disorder: results from the Canadian Rapid Treatment Center of Excellence. Journal of Affective Disorders, 274, 903-910.

https://www.sciencedirect.com/science/article/pii/S0165032720301853

 

  1. Ketamine infusions for suicidal ideation: 

Phillips, J. L., Norris, S., Talbot, J., Hatchard, T., Ortiz, A., Birmingham, M., … & Blier, P. (2020). Single and repeated ketamine infusions for reduction of suicidal ideation in treatment-resistant depression. Neuropsychopharmacology, 45(4), 606-612.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021716/pdf/41386_2019_Article_570.pdf

 

  1. Racemic IV ketamine v. Nasal esketamine

Bahji, A., Vazquez, G. H., & Zarate Jr, C. A. (2021). Comparative efficacy of racemic ketamine and esketamine for depression: a systematic review and meta-analysis. Journal of affective disorders, 278, 542-555.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704936/pdf/nihms-1633036.pdf

 

  1. Ketamine infusions for PTSD

Feder, A., Costi, S., Rutter, S. B., Collins, A. B., Govindarajulu, U., Jha, M. K., … & Charney, D. S. (2021). A randomized controlled trial of repeated ketamine administration for chronic posttraumatic stress disorder. American Journal of Psychiatry, 178(2), 193-202.

https://ajp.psychiatryonline.org/doi/pdf/10.1176/appi.ajp.2020.20050596

 

  1. Ketamine for infusions for anxiety

McIntyre, R. S., Rodrigues, N. B., Lee, Y., Lipsitz, O., Subramaniapillai, M., Gill, H., … & Rosenblat, J. D. (2020). The effectiveness of repeated intravenous ketamine on depressive symptoms, suicidal ideation, and functional disability in adults with major depressive disorder and bipolar disorder: results from the Canadian Rapid Treatment Center of Excellence. Journal of Affective Disorders, 274, 903-910.

https://www.sciencedirect.com/science/article/pii/S0165032720301853

Whittaker, E., Dadabayev, A. R., Joshi, S. A., & Glue, P. (2021). Systematic review and meta-analysis of randomized controlled trials of ketamine in the treatment of refractory anxiety spectrum disorders. Therapeutic Advances in Psychopharmacology, 11, 20451253211056743.

https://journals.sagepub.com/doi/pdf/10.1177/20451253211056743

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