The leading ketamine infusion clinic in Winston-Salem, NC

Depression Treatment

Treatment Tailored to Your Specific Needs

What Is Depression?

Depression causes feelings of sadness and/or a loss of interest in activities you once enjoyed. It can lead to a variety of emotional and physical problems and can decrease your ability to function at work and at home.

Chronic treatment-resistant depression, however, is a mood disorder that doesn’t respond to traditional treatments. Often it can leave a person feeling hopeless, trying multiple treatment methods with no success. 

At Restoring Wellness Solutions, we know how debilitating this condition can be. That’s why we are committed to treating not just the symptoms, but the underlying condition unique to each of our patients.

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Ketamine and NMDA

Ketamine is in a class of drugs called NMDA (short for N-methyl-D-aspartate) receptor antagonists, which have been shown to be effective in the treatment of major depressive disorder and other mental health conditions. Research shows that ketamine positively affects a wide range of cellular processes, including the blockade of NMDA channels. While ketamine blocks NMDA receptors; it produces a paradoxical increase in brain levels of glutamate, the neurotransmitter that excites NMDA receptors. Recent studies that found that a low dose of ketamine, which alters glutamate system activity, can rapidly eliminate depression in two-thirds of patients who do not respond to conventional antidepressants.

Ketamine and Glutamate

Neurons in the brain need a chemical called glutamate to communicate with each other. The neurons need glutamate receptors -- like a boat dock for glutamate -- to communicate. Clinical studies have shown IV ketamine therapy works by helping to “restock” the brain’s neurons with new glutamate receptors, allowing for the neurons to communicate with each other along new pathways. This process has been shown to have significant positive effects on mood disorders like treatment-resistant depression and severe anxiety. Many patients report a substantial reduction in their symptoms after just one infusion.

Ketamine VS Antidepressants

According to the World Health Organization, depression affects nearly 300 million people worldwide. Despite its prevalence, traditional antidepressants such as selective serotonin reuptake inhibitors are only effective in treating about 30% of patients suffering from mood disorders. Oral antidepressants also typically require several weeks to several months to produce a therapeutic response. IV ketamine therapy, on the other hand, has been shown to reduce symptoms in patients in as little as 4 hours after the first infusion.
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The Biggest Breakthrough in Decades

How Ketamine Treats Depression

Many traditional treatment options, like antidepressant pills, take weeks to months for patients to feel any effects. For some, the relief never comes. The reason doctors are calling ketamine a significant breakthrough in depression treatment is due to its ability to help patients feel relief within days, sometimes even hours. 

Studies show that up to 70% of patients report improvement in their symptoms after just a single ketamine infusion.

Ketamine treatment at Restoring Wellness Solutions works by targeting the depression itself by interacting with the NMDA receptor and glutamate – two parts of the brain essential for communication and connection.

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Restoring Wellness is Here to Help

We believe ketamine therapy is part of a comprehensive mental health plan, and we look forward to collaborating with primary mental health providers.

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